Current Issue : July - September Volume : 2020 Issue Number : 3 Articles : 5 Articles
Abstract: Removing head louse eggshells and nits after a successful pediculicide treatment is often\nmade more difficult because it is not easy to see them all amongst the hairs. Therefore, a treatment that\nmakes louse eggs more visible potentially makes the task of removal easier and reduces the risk that\nchildren would be sent home from school or over-treated. This project involved the development of a\nhair treatment gel concept that was easy to apply, wash out, and that stained louse eggs and nits but\nwithout staining the hair and skin. A series of food-grade dyes were evaluated for their ability to stain\nthe eggshells, and various copolymer-based rheology modifiers were tested for dye compatibility\nand stability. Several dyes were rejected because either they failed to stain louse eggshells or else\nstained skin too easily. Two dyes, Patent Blue and Ponceau 4R, were eventually selected for different\nproduct developments, one specifically for post-treatment nit removal and the other for pre-treatment\ndiagnosis. In clinical field studies, both were found to make the treated eggshells contrast sufficiently\nwith the hair to enable identification of persistent nits. Use of a nit stain product can enable easier\ndetection of louse eggs and nits, thus facilitating the removal process and reducing the risk that\npersistent eggshells could be mistaken for signs of a continuing infestation....
Abstract: Ultraviolet A (UVA)-induced detrimental effects in the skin, also known as photoaging,\nare mediated with several pathways including oxidative stress generation and extracellular matrix\n(ECM) degradation. UVA irradiation results in excessive production of matrix metalloproteinases\n(MMPs), enzymes responsible for the degradation of ECM components such as collagen. In this\nstudy, the protective effects of (2'S)-columbianetin against UVA-induced changes in matrix\nmetalloproteinase-1 (MMP-1) and collagen production were investigated in human dermal fibroblasts\n(HDFs). The (2'S)-columbianetin was isolated from Corydalis heterocarpa. UVA exposure increased\nMMP-1 release from HDFs and diminished the release of type I pro-collagen. Treatment with\n(2'S)-columbianetin reversed these effects of UVA exposure. The (2'S)-columbianetin treatment also\nsuppressed the intracellular expression of MMP-1 and increased type I pro-collagen expression.\nUVA exposure elevated the activation of p38, c-Jun-amino-terminal kinase (JNK) and extracellular\nsignal-related kinase (ERK) as the mechanism to stimulateMMP-1production. The (2'S)-columbianetin\nsuppressed the phosphorylation of JNK and ERK. The (2'S)-columbianetin was also stimulated\ncollagen production via TGFBeta signaling cascade, relieving UVA-induced suppression of Smad2/3\nphosphorylation and translocation. In conclusion, (2'S)-columbianetin was suggested to be a\npotential cosmeceutical lead compound with antiphotoaging properties against UVA-induced\ncollagen degradation....
Abstract: A deteriorating nail standard is a growing problem as the global prevalence of diabetes is\nincreasing. Systemic treatment with mineral supplements may not be recommended, mainly due to\nthe high doses required to deliver optimal therapeutic concentrations. In this work, we evaluate nail\npolish formulations for the local delivery of strengthening elements to the nail plate. Specifically,\nwe assess calcium and silicon release from nail polish base coat formulations containing three\ndifferent concentrations of White Portland Cement to water, as well as to artificial and human nails.\nThe delivery of calcium and silicon to the dorsal nail plate was determined by inductively coupled\nplasma optical emission spectrometry, scanning electron microscopy, and energy dispersive X-ray\nspectroscopy. To the best of our knowledge, this is the first study showing that such dual elemental\ndelivery to human nails can be achieved from nail polish formulations. Hence, this work may form\nthe basis for new inventions where therapeutic functionalities can be integrated with the mechanical\nand cosmetic properties of a base coat nail polish. Future permeability studies are required to verify\nlong-term effects on the nail standard, induced by the formulations under study....
Abstract: Fucoxanthin is a bioactive compound that is a kind of natural carotenoid. Fucoxanthin\nis known to protect against UV-B-induced cell damage in hairless mice, even though it is\nphysiochemically unstable to heat and acid due to its polyunsaturated structure, indicating that\nfucoxanthin possesses a low bioavailability, and this disadvantage limits its application in the\ncosmetic industry. Solid lipid nanoparticle (SLN) systems are known to be suitable as carriers for\nsunscreen agents. In this research work, the sunscreen-boosting effect of SLN, as a deliverer of\nfunctional ingredient, especially fucoxanthin, has been developed and evaluated by comparing the\nsunburn protection factors (SPF) of macroemulsion (cream and lotion type) and an SLN formula\ncontaining various kinds of sunscreen agents, respectively. Several results such as stability test,\nparticle size, DSC analysis, and X-ray analysis show that the SLN formula loading fucoxanthin has\nthe possibility of being a stable and high-functioning ingredient delivery system. Moreover, the\nSLN formula has shown a higher SPF value than others, meaning that the SLN formula exhibits a\ngood sunscreen-boosting effect. This study indicates that the use of SLN as a carrier enhanced the\nbioavailability of fucoxanthin and shows that SLN could be a promising carrier for the production of\nsunscreen products by allowing the scaling-up of production....
Abstract: Several of most common dermatoses worldwide, e.g., psoriasis and atopic dermatitis,\nare worsened in their clinical picture when the skin is regularly exposed to an increased air pollution\nlevel, e.g., particulate matter. This is explainable by the activation of the aryl hydrocarbon receptor\n(AhR) in the skin, which results in an increased release of proinflammatory cytokines and matrix\nmetalloproteinases. Symurban is a competitive AhR antagonist and thus allows the effective protection\nof skin. In order to improve its dermal bioavailability as a poorly soluble active agent (0.25 microg/mL),\nnanocrystals were prepared and evaluated. Nanocrystals are pure active crystals reduced in particle\nsize to the submicron range of 100 to 1000 nm. They feature the properties of nanocrystals, such as\nincreased saturation solubility and dissolution velocity, without having to be declared as nanomaterial.\nProduction methods and parameters were systematically investigated. Wet bead milling at 2000 rpm\nfor 30 min yielded the best results.Az-average of 280nmwas achieved for a 10% Symurban suspension\nwith a polydispersity index of 0.20, indicating a narrowsize distribution. For the long-term stabilization\nof the nanocrystal suspension, the performance of 15 surfactants of different categories and HLB\nvalues were investigated and evaluated. It was found that non-ionic surfactants in general were\nbetter able to stabilize the system than anionic or amphoteric surfactants. Highest stability of over 12\nmonths at 25 Degree C was achieved with 2% Plantacare 810 UP, an ECOCERT surfactant with high skin\ntolerance. The suspension was also chemically long-term stable with >97% of remaining Symurban\nover 12 months. The saturation solubility of Symurban as nanocrystals was significantly increased\nfrom 0.25 to 2.9 micro g/mL, which corresponds to a factor of >11. In a case study of one male volunteer\nwith healthy skin conditions, penetration profiles of Symurban nanocrystal hydrogel and commercial\nanti-pollution serum containing an identical amount of Symurban were determined and compared.\nAfter 20 min of exposure, the relative Symurban concentration in the deeper skin layers (tape 19-30)\nwas more than two times higher for nanocrystal hydrogel (16%) than the commercial serum (7%).\nThese results suggest that nanocrystals are a promising delivery system for the poorly soluble\nanti-pollution agent Symurban....
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